BCL2L2
Gene Ontology | |
---|---|
Molecular function | • protein binding |
Cellular component | • cytosol • mitochondrial membrane |
Biological process | • apoptotic process • spermatogenesis • negative regulation of apoptotic process • Sertoli cell proliferation |
Sources: Amigo / QuickGO |
23.77 – 23.78 Mb
54.88 – 54.89 Mb
Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene.
This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
Relative to its Bcl-2 counterparts there is considerably less data on this particular protein however much effort is being made to further understand its cellular roles. Located on chromosome 14q11 it appears to be redundant in most tissues apart from specific examples. It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w..
Read more about BCL2L2: Interactions