BCL2L2

BCL2L2

Identifiers Symbols BCL2L2; BCL-W; BCL2-L-2; BCLW; PPP1R51 External IDs OMIM: 601931 MGI: 108052 HomoloGene: 2989 ChEMBL: 4677 GeneCards: BCL2L2 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• cytosol • mitochondrial membrane
Biological process	• apoptotic process • spermatogenesis • negative regulation of apoptotic process • Sertoli cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 599 12050 Ensembl ENSG00000129473 ENSMUSG00000089682 UniProt Q92843 P70345 RefSeq (mRNA) NM_001199839 NM_007537 RefSeq (protein) NP_001186768 NP_031563 Location (UCSC) Chr 14:
23.77 – 23.78 Mb Chr 14:
54.88 – 54.89 Mb PubMed search

Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene.

This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

Relative to its Bcl-2 counterparts there is considerably less data on this particular protein however much effort is being made to further understand its cellular roles. Located on chromosome 14q11 it appears to be redundant in most tissues apart from specific examples. It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w..