BCL2L11

BCL2L11

Identifiers Symbols BCL2L11; BAM; BIM; BOD External IDs OMIM: 603827 MGI: 1197519 HomoloGene: 7643 ChEMBL: 5777 GeneCards: BCL2L11 Gene

Gene Ontology
Molecular function	• protein binding • microtubule binding
Cellular component	• mitochondrial outer membrane • cytosol • microtubule • plasma membrane • endomembrane system • BIM-BCL-xl complex • BIM-BCL-2 complex
Biological process	• in utero embryonic development • B cell homeostasis • B cell apoptotic process • kidney development • myeloid cell homeostasis • apoptotic process • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell-matrix adhesion • spermatogenesis • male gonad development • mammary gland development • positive regulation of protein homooligomerization • response to endoplasmic reticulum stress • tube formation • odontogenesis of dentin-containing tooth • T cell homeostasis • positive regulation of apoptotic process • positive regulation of neuron apoptotic process • ear development • positive regulation of cell cycle • regulation of organ growth • nerve growth factor receptor signaling pathway • developmental pigmentation • regulation of developmental pigmentation • spleen development • thymus development • post-embryonic organ morphogenesis • cellular process regulating host cell cycle in response to virus • positive regulation of release of cytochrome c from mitochondria • positive regulation of intrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10018 12125 Ensembl ENSG00000153094 ENSMUSG00000027381 UniProt O43521 O54918 RefSeq (mRNA) NM_001204106 NM_009754 RefSeq (protein) NP_001191035 NP_033884 Location (UCSC) Chr 2:
111.88 – 111.92 Mb Chr 2:
128.13 – 128.16 Mb PubMed search

Bcl-2-like protein 11 is a protein that in humans is encoded by the BCL2L11 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.