BCL2-related Protein A1

BCL2-related Protein A1

Identifiers Symbols BCL2A1; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1 External IDs OMIM: 601056 MGI: 102687 HomoloGene: 2988 ChEMBL: 6044 GeneCards: BCL2A1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• cytoplasm
Biological process	• apoptotic process • negative regulation of apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 597 12044 Ensembl ENSG00000140379 ENSMUSG00000093809 UniProt Q16548 Q07440 RefSeq (mRNA) NM_001114735 NM_009742 RefSeq (protein) NP_001108207 NP_033872 Location (UCSC) Chr 15:
80.25 – 80.26 Mb Chr 9:
88.96 – 88.96 Mb PubMed search

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.

This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

In melanocytic cells BCL2A1 gene expression may be regulated by MITF.