BCL2-like 1 (gene)

BCL2-like 1 (gene)

Identifiers Symbols BCL2L1; BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-X; PPP1R52; bcl-xL; bcl-xS External IDs OMIM: 600039 MGI: 88139 HomoloGene: 7639 ChEMBL: 4625 GeneCards: BCL2L1 Gene

Gene Ontology
Molecular function	• protein binding • protein kinase binding • identical protein binding • protein heterodimerization activity • BH3 domain binding
Cellular component	• cytoplasm • mitochondrion • mitochondrial outer membrane • centrosome • cytosol • integral to membrane • nuclear membrane • Bcl-2 family protein complex
Biological process	• cytokinesis • ovarian follicle development • in utero embryonic development • release of cytochrome c from mitochondria • apoptotic process • germ cell development • spermatogenesis • cell proliferation • positive regulation of cell proliferation • male gonad development • apoptotic mitochondrial changes • fertilization • negative regulation of autophagy • response to cytokine stimulus • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • growth • positive regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of neuron apoptotic process • innate immune response • response to cycloheximide • regulation of mitochondrial membrane permeability • regulation of mitochondrial membrane potential • cellular process regulating host cell cycle in response to virus • cellular response to amino acid stimulus • cellular response to alkaloid • cellular response to gamma radiation • mitotic cell cycle G2/M transition checkpoint • negative regulation of establishment of protein localization to plasma membrane • negative regulation of release of cytochrome c from mitochondria • negative regulation of anoikis • negative regulation of intrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 598 12048 Ensembl ENSG00000171552 ENSMUSG00000007659 UniProt Q07817 Q64373 RefSeq (mRNA) NM_001191 NM_009743 RefSeq (protein) NP_001182 NP_033873 Location (UCSC) Chr 20:
30.25 – 30.31 Mb Chr 2:
152.78 – 152.83 Mb PubMed search

Bcl-2-like protein 1 is a protein that in humans is encoded by the BCL2L1 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species(ROS) and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.