Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
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Famous quotes containing the word killer:
“I see the killer in him
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and on a pie plate he sticks
in my Yellow Star....”
—Anne Sexton (1928–1974)