Barrier To Autointegration Factor 1
| Gene Ontology | |
|---|---|
| Molecular function | • DNA binding • protein binding |
| Cellular component | • nucleoplasm • chromosome • cytosol |
| Biological process | • response to virus • DNA integration • viral reproduction • virus-host interaction |
| Sources: Amigo / QuickGO | |
65.77 – 65.77 Mb
5.36 – 5.37 Mb
Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene. It is a member of the barrier-to-autointegration factor family of proteins.
The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina. It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1.
Read more about Barrier To Autointegration Factor 1: Interactions, Clinical Relevance
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