Comparison To Other Mazes
The Barnes Maze is similar to the Morris water navigation task and to the Radial arm maze task, but does not utilize a strong aversive stimuli (stress induced by swimming such as in the Morris Water Maze) or deprivation (food or water deprivation such as in the Radial Arm Maze) is being used as reinforcement. Behavioral tasks involving high levels of stress can influence the animal's performance on the task, making the Barnes Maze ideal for eliminating stress-induced confounds. However, due to the lack of a strong aversive stimuli, some rodents may lack motivation to complete the task. Once acclimated to the maze, subjects may prefer to explore instead of complete the task. Using different parameters to analyze the data is important for avoiding this issue. Latency, path length to escape box, and number of errors to the first nose poke at the escape hole have been used as measures previously. Another drawback to the Barnes Maze is that when testing multiple animals, scent cues left on the maze by the previous animal could alter the performance of subsequent subjects.
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