Band 3

Band 3

Identifiers Symbols SLC4A1; AE1; BND3; CD233; DI; EMPB3; EPB3; FR; RTA1A; SW; WD; WD1; WR External IDs OMIM: 109270 MGI: 109393 HomoloGene: 37290 GeneCards: SLC4A1 Gene

Gene Ontology
Molecular function actin binding
inorganic anion exchanger activity
protein binding
protein C-terminus binding
anion transmembrane transporter activity
chloride transmembrane transporter activity
anion:anion antiporter activity
ankyrin binding
protein homodimerization activity
protein anchor
Cellular component plasma membrane
integral to plasma membrane
integral to membrane
basolateral plasma membrane
Z disc
cortical cytoskeleton
Biological process ion transport
anion transport
chloride transport
cellular ion homeostasis
bicarbonate transport
small molecule metabolic process
transmembrane transport
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6521 20533 Ensembl ENSG00000004939 ENSMUSG00000006574 UniProt P02730 P04919 RefSeq (mRNA) NM_000342.3 NM_011403.2 RefSeq (protein) NP_000333.1 NP_035533.1 Location (UCSC) Chr 17:
42.33 – 42.35 Mb Chr 11:
102.35 – 102.37 Mb PubMed search
solute carrier family 4 (anion exchanger), member 1, adapter protein
Identifiers
Symbol SLC4A1AP
Entrez 22950
HUGO 13813
OMIM 602655
RefSeq NM_018158
UniProt P02730
Other data
Locus Chr. 2 p23.3

Anion Exchanger 1 (AE1) or Band 3 is a phylogenetically preserved transport protein responsible for mediating the exchange of chloride (Cl-) for bicarbonate (HCO3-) across a plasma membrane. Functionally similar members of the AE clade are AE2 and AE3.

It is ubiquitous throughout the vertebrates. In humans it is present in two specific sites:

  • the erythrocyte (red blood cell) cell membrane and
  • the basolateral surface of the alpha-intercalated cell (the acid secreting cell type) in the collecting duct of the kidney.

The erythrocyte and kidney forms are different isoforms of the same protein.

Read more about Band 3:  Discovery, AE1 in Red Cells, AE1 in Alpha-Intercalated Cells, Interactions

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