Band 3
Gene Ontology | |
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Molecular function | • actin binding • inorganic anion exchanger activity • protein binding • protein C-terminus binding • anion transmembrane transporter activity • chloride transmembrane transporter activity • anion:anion antiporter activity • ankyrin binding • protein homodimerization activity • protein anchor |
Cellular component | • plasma membrane • integral to plasma membrane • integral to membrane • basolateral plasma membrane • Z disc • cortical cytoskeleton |
Biological process | • ion transport • anion transport • chloride transport • cellular ion homeostasis • bicarbonate transport • small molecule metabolic process • transmembrane transport |
Sources: Amigo / QuickGO |
42.33 – 42.35 Mb
102.35 – 102.37 Mb
solute carrier family 4 (anion exchanger), member 1, adapter protein | |
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Identifiers | |
Symbol | SLC4A1AP |
Entrez | 22950 |
HUGO | 13813 |
OMIM | 602655 |
RefSeq | NM_018158 |
UniProt | P02730 |
Other data | |
Locus | Chr. 2 p23.3 |
Anion Exchanger 1 (AE1) or Band 3 is a phylogenetically preserved transport protein responsible for mediating the exchange of chloride (Cl-) for bicarbonate (HCO3-) across a plasma membrane. Functionally similar members of the AE clade are AE2 and AE3.
It is ubiquitous throughout the vertebrates. In humans it is present in two specific sites:
- the erythrocyte (red blood cell) cell membrane and
- the basolateral surface of the alpha-intercalated cell (the acid secreting cell type) in the collecting duct of the kidney.
The erythrocyte and kidney forms are different isoforms of the same protein.
Read more about Band 3: Discovery, AE1 in Red Cells, AE1 in Alpha-Intercalated Cells, Interactions
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