Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is an epileptic disorder that causes frequent violent seizures during sleep. These seizures often involve complex motor movements, such as hand clenching, arm raising/lowering, and knee bending. Vocalizations such as shouting, moaning, or crying are also common. ADNFLE is often misdiagnosed as nightmares. Attacks often occur in clusters and typically first manifest in childhood. There are four known loci for ADNFLE, three with known causative genes. These genes encode various nicotinic acetylcholine receptor α and β subunits CHRNA4, CHRNB2, and CHRNA2.
| Autosomal dominant nocturnal frontal lobe epilepsy | |
|---|---|
| Classification and external resources | |
| OMIM | 600513 603204 605375 610353 |
Read more about Autosomal Dominant Nocturnal Frontal Lobe Epilepsy: Signs and Symptoms, Causes, Diagnosis, Treatment/Management
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