Asplenia - Risks

Risks

Asplenia is a form of immunodeficiency, increasing the risk of sepsis from polysaccharide encapsulated bacteria, and can result in overwhelming post splenectomy infection (OPSI), often fatal within a few hours. In particular, patients are at risk from Pneumococcus, Haemophilus influenzae, and meningococcus. The risk is elevated as much as 350–fold.

The risk to asplenic patients has been expressed as equivalent to a child dying in a home accident, or equivalent to an adult dying in a road traffic accident (reference UK Splenectomy Trust Advice)—hence sensible precautions are advisable.

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