Computing
- APC (magazine), a computer magazine in Australia
- Adaptive predictive coding, an analog-to-digital conversion system
- Advanced process control, a broad term within the control theory
- Alternative PHP Cache, a PHP accelerator program
- Application Program Command, a C1 control code
- APC III or Advanced Personal Computer, a 1983 NEC microcomputer
- Asynchronous Procedure Call, a facility in the Microsoft Windows (Win32) API (Microsoft documentation)
- VIA APC (Android PC System), a Raspberry Pi competitor product from VIA Technologies
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