AP2 may refer to:
- Activating protein 2, a mammalian transcription factor
- Adipocyte protein 2, a carrier protein for fatty acids
- AP2 adaptors, which aid clathrin mediated endocytosis
- Apetala 2, a plant transcription factor
- Amiga Power, the follow-up website to Amiga gaming magazine
- American Pie 2, a movie
- Argyle Park, industrial/experimental band
- Autopista AP-2, a roadway in Spain