Andrew McDonald may refer to:
- Andrew MacDonald (ice hockey) (born 1986), Canadian ice hockey defenceman
- Andrew McDonald (water polo) (born 1955), American Olympic water polo player
- Andrew McDonald (Australian politician) (born 1955), Australian doctor and politician
- Andrew McDonald (cricketer) (born 1981), Australian cricketer
- Andrew McDonald (wrestler)
- Andrew J. McDonald, American lawyer and politician from Connecticut
- Andrew Joseph McDonald (born 1923), American prelate of the Roman Catholic Church, Bishop of Little Rock, 1972–2000
- Andrew Thomas McDonald (1871–1950), Roman Catholic Archbishop
- Andy Macdonald (skateboarding), American professional skateboarder
- Andy McDonald (ice hockey) (born 1977), Canadian professional ice hockey centre and winger
- Andy McDonald (politician) (born 1958), British Labour MP for Middlesbrough
- Andy McDonald (Coronation Street), fictional character on the TV soap opera Coronation Street
- Andy McDonald (footballer) (1885–1967), Australian rules footballer
- Drew McDonald (born 1955), British Olympic wrestler
- Sir Andrew McDonald, Lord Provost of Edinburgh, 1894–1897