In Greek mythology, in a myth assigned to Euripides by the Bibliotheca, Amphilochus is the son of Alcmaeon, one of the Epigoni, and Manto, the daughter of the Theban seer Teiresias.
Manto is sent to Delphi and then to Caria, and Alcmaeon entrusts young Amphilochus and his sister, Tisiphone, to king Creon of Corinth to be raised, but the queen of Corinth sells Tisiphone into slavery. Alcmaeon eventually recovers his children (the story is told in Alcmaeon in Corinth a lost play by Euripides). Amphilochus goes on to found Amphilochian Argos.
After the Trojan War, he may have been killed either by Apollo, or by his younger half-brother Mopsus (son of Manto and Rhacius of Crete). Mopsus and Amphilochus quarreled over the rulership of Mallos in Cicilia, and they killed each other in combat.
Alcmaeon had a brother named Amphilocus, who is named among the suitors of Helen in some accounts.