Adrenocortical Hyperfunction

Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal cortex.

When cortisol is overproduced, it is called Cushing's syndrome.

When aldosterone is overproduced, it is called hyperaldosteronism.

Endocrine pathology: endocrine diseases (E00–E35, 240–259)
Pancreas/
glucose
metabolism
Hypofunction
  • Diabetes mellitus
  • types:
    • type 1
    • type 2
    • MODY 1 2 3 4 5 6
  • complications
    • coma
    • angiopathy
    • ketoacidosis
    • nephropathy
    • neuropathy
    • retinopathy
    • cardiomyopathy
  • insulin receptor (Rabson–Mendenhall syndrome)
  • Insulin resistance
Hyperfunction
  • Hypoglycemia
  • beta cell (Hyperinsulinism)
  • G cell (Zollinger–Ellison syndrome)
Hypothalamic/
pituitary axes
Hypothalamus
  • gonadotropin
    • Kallmann syndrome
    • Adiposogenital dystrophy
  • CRH (Tertiary adrenal insufficiency)
  • vasopressin (Neurogenic diabetes insipidus)
  • general (Hypothalamic hamartoma)
Pituitary
Hyperpituitarism
  • anterior
    • Acromegaly
    • Hyperprolactinaemia
    • Pituitary ACTH hypersecretion
  • posterior (SIADH)
  • general (Nelson's syndrome)
Hypopituitarism
  • anterior
    • Kallmann syndrome
    • Growth hormone deficiency
    • ACTH deficiency/Secondary adrenal insufficiency
    • GnRH insensitivity
    • FSH insensitivity
    • LH/hCG insensitivity
  • posterior (Neurogenic diabetes insipidus)
  • general
    • Empty sella syndrome
    • Pituitary apoplexy
    • Sheehan's syndrome
    • Lymphocytic hypophysitis
Thyroid
Hypothyroidism
  • Iodine deficiency
  • Cretinism
    • Congenital hypothyroidism
  • Myxedema
  • Euthyroid sick syndrome
Hyperthyroidism
  • Hyperthyroxinemia
    • Thyroid hormone resistance
    • Familial dysalbuminemic hyperthyroxinemia
  • Hashitoxicosis
  • Thyrotoxicosis factitia
  • Graves' disease
Thyroiditis
  • Acute infectious
  • Subacute
    • De Quervain's
    • Subacute lymphocytic
  • Autoimmune/chronic
    • Hashimoto's
    • Postpartum
    • Riedel's
Goitre
  • Endemic goitre
  • Toxic nodular goitre
  • Toxic multinodular goiter
  • Thyroid nodule
Parathyroid
Hypoparathyroidism
  • Hypoparathyroidism
  • Pseudohypoparathyroidism
  • Pseudopseudohypoparathyroidism
Hyperparathyroidism
  • Primary
  • Secondary
  • Tertiary
  • Osteitis fibrosa cystica
Adrenal
Hyperfunction
  • aldosterone: Hyperaldosteronism/Primary aldosteronism
    • Conn syndrome
    • Bartter syndrome
    • Glucocorticoid remediable aldosteronism
  • AME
  • Liddle's syndrome
  • 17α CAH
  • cortisol: Cushing's syndrome (Pseudo-Cushing's syndrome)
  • sex hormones: 21α CAH
  • 11β CAH
Hypofunction/
Adrenal insufficiency
(Addison's, WF)
  • aldosterone: Hypoaldosteronism
    • 21α CAH
    • 11β CAH
  • cortisol: CAH
    • Lipoid
    • 3β
    • 11β
    • 17α
    • 21α
  • sex hormones: 17α CAH
Gonads
  • ovarian: Polycystic ovary syndrome
  • Premature ovarian failure
  • testicular: enzymatic
    • 5α-reductase deficiency
    • 17β-hydroxysteroid dehydrogenase deficiency
    • aromatase excess syndrome)
  • Androgen receptor (Androgen insensitivity syndrome
  • general: Hypogonadism (Delayed puberty)
  • Hypergonadism
    • Precocious puberty
  • Hypoandrogenism
  • Hypoestrogenism
  • Hyperandrogenism
  • Hyperestrogenism
Height
  • Dwarfism/Short stature
    • Laron syndrome
    • Psychosocial
  • Gigantism
Multiple
  • Autoimmune polyendocrine syndrome multiple
    • APS1
    • APS2
  • Carcinoid syndrome
  • Multiple endocrine neoplasia
    • 1
    • 2A
    • 2B
  • Progeria
    • Werner syndrome
    • Acrogeria
    • Metageria
  • Woodhouse-Sakati syndrome

M: END

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