Adair Crawford - Calorimetric Work

Calorimetric Work

Crawford's book "Experimental Enquiry into the Effects of Tonics and Other Medicinal Substances on the Cohesion of Animal Fibre", written near the end of his life, offers a very readable presentation of his way of doing chemistry. Here's an example:

With a view to determine the changes which animal fibre might undergo by exposing it to the action of Port wine, six portions of the small intestines of a kitten were taken. Three of these were introduced into a phial, which was nearly filled with Port wine, and closed with a cork; and the remaining three were immersed in water, as a standard. Being placed in a cool situation during three days, the portions in contact with the wine were found to have greater firmness than those that were immersed in the water. The sum of the weights required to break the former was 9 lb. 0 oz.; the sum of those required to break the latter was 7 lb. 4 oz. .... With a view to guard against error in trials of this nature, it is of importance that the portions of the intestine should be as nearly as possible of the same length. They should likewise have nearly the same degree of curvature. For a very curved portion of the intestine is more easily broken than a straight one.... If the trials be frequently repeated, results will be obtained that approach near to the truth.... From the foregoing trials, it appears, that the firmness, elasticity, and strength of the intestines of a kitten are considerably increased by immersing them three days in Port wine. I have found, however, that a much less time than this is sufficient for the wine to produce its full effect. In several experiments a manifest increase of cohesion appeared to have taken place in less than an hour; and after ten hours have elapsed, I believe no farther augmentation is produced.