Lethal Dose
LD50 values for mice are 1 mg/kg orally, 0.100 mg/kg intravenously, 0.270 mg/kg intraperitoneally and 0.270 mg/kg subcutaneously. The lowest published lethal dose (LDLo) for mice is 1 mg/kg orally and 0.100 mg/kg intraperitoneally. The lowest published toxic dose (TDLo) for mice is 0.0549 mg/kg subcutaneously. LD50 value for rats is 0.064 mg/kg intraveneously. The LDLo for rats is 0.040 mg/kg intravenously and 0.250 mg/kg intraperitoneally. The TDLo for rats is 0.040 mg/kg parenterally. For an overview of more test animal results (LD50, LDLo and TDLo) see the following table.
| Species Observed | Type of Test | Route of Exposure | Dose Data (mg/kg) | Toxic Effects |
|---|---|---|---|---|
| Human | LDLo | Oral | 0.028 | Behavioral - excitement
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes |
| Human | LDLo | Oral | 0.029 | Details of toxic effects not reported other than lethal dose value |
| Cat | LD50 | Intravenous | 0.080 | Behavioral - convulsions or effect on seizure threshold |
| Cat | LDLo | Subcutaneous | 0.100 | Details of toxic effects not reported other than lethal dose value |
| Guinea pig | LD50 | Intravenous | 0.060 | Behavioral - convulsions or effect on seizure threshold |
| Guinea pig | LDLo | Subcutaneous | 0.050 | Details of toxic effects not reported other than lethal dose value |
| Guinea pig | LDLo | Intravenous | 0.025 | Cardiac - arrhythmias (including changes in conduction) |
| Mouse | LD50 | Intraperitoneal | 0.270 | Details of toxic effects not reported other than lethal dose value |
| Mouse | LD50 | Intravenous | 0.100 | Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea |
| Mouse | LD50 | Oral | 1 | Details of toxic effects not reported other than lethal dose value |
| Mouse | LD50 | Subcutaneous | 0.270 | Details of toxic effects not reported other than lethal dose value |
| Mouse | LDLo | Intraperitoneal | 0.100 | Details of toxic effects not reported other than lethal dose value |
| Mouse | LDLo | Oral | 1 | Behavioral - convulsions or effect on seizure threshold
Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - hypermotility, diarrhea |
| Mouse | TDLo | Subcutaneous | 0.0549 | Peripheral Nerve and Sensation - local anesthetic
Behavioral - analgesia |
| Rabbit | LDLo | Subcutaneous | 0.131 | Details of toxic effects not reported other than lethal dose value |
| Rat | LD50 | Intravenous | 0.080 | Behavioral - convulsions or effect on seizure threshold |
| Rat | LD50 | Intravenous | 0.064 | Details of toxic effects not reported other than lethal dose value |
| Rat | LDLo | Intraperitoneal | 0.250 | Cardiac - other changes;Lungs, Thorax, or Respiration - dyspnea |
| Rat | LDLo | Intravenous | 0.040 | Cardiac - arrhythmias (including changes in conduction) |
| Rat | TDLo | Parenteral | 0.040 | Cardiac - arrhythmias (including changes in conduction) |
| Frog | LDLo | Subcutaneous | 0.586 | Details of toxic effects not reported other than lethal dose value |
| Pigeon | LDLo | Subcutaneous | 0.066 | Details of toxic effects not reported other than lethal dose value |
- note that LD50 means lethal dose, 50 percent kill; LDLo means lowest published lethal dose; TDLo means lowest published toxic dose
For humans the lowest published oral lethal dose of 28 μg/kg was reported in 1969.
Read more about this topic: Aconitine
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