Acetylserotonin O-methyltransferase

Acetylserotonin O-methyltransferase

Identifiers Symbols ASMT; ASMTY; HIOMT; HIOMTY External IDs OMIM: 402500 MGI: 96090 HomoloGene: 48261 GeneCards: ASMT Gene EC number 2.1.1.4

Gene Ontology
Molecular function	• O-methyltransferase activity • acetylserotonin O-methyltransferase activity
Cellular component	• cytosol
Biological process	• translation • melatonin biosynthetic process • cellular nitrogen compound metabolic process • small molecule metabolic process • indolalkylamine biosynthetic process
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 438 n/a Ensembl ENSG00000196433 n/a UniProt P46597 n/a RefSeq (mRNA) NM_001171038.1 n/a RefSeq (protein) NP_001164509.1 n/a Location (UCSC) Chr X:
1.73 – 1.76 Mb n/a PubMed search n/a

N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.

In humans the ASMT enzyme is encoded by the ASMT gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.