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- Samuel Warren Abbott (1837–1904), American physician
- Saunders Alexius Abbott (1811–1894), British general
- Scott Abbott, Canadian co-creator of popular board game Trivial Pursuit
- Senda Berenson Abbott (1868–1964), Lithuanian basketballer
- Shirley Abbott (1889 - unknown), British footballer
- Steve Abbott (born 1956), Australian comedian
- Stuart Abbott (born 1978), South African rugby union player
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