The 2007 Stanford vs. Southern California football game was a college football game held on October 6, 2007, at the Los Angeles Memorial Coliseum in Los Angeles, California. In a remarkable upset, the visiting Stanford Cardinal won 24–23. Southern California (USC) was favored by 41 points over Stanford, making the game the largest point spread upset in college football history. USC entered the game with a 35-game home game winning streak (its previous home game loss was also happened to be to Stanford, in 2001) which included a 24-game home game winning streak in Pac-10 play. By contrast, Stanford had compiled a Pac-10 worst 1–11 season in 2006 which included a 42–0 loss to USC. To compound their situation, Stanford's starting quarterback, T. C. Ostrander, had suffered a seizure the previous week; the backup quarterback, Tavita Pritchard had never started a game and had only ever thrown three passes.
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