Zzyzx, Zyzzyx, Zzyzx Road or Zyzzx Road, usually pronounced /ˈzaɪzɨks/, may refer to:
- Zzyzx, California, U.S., and Zzyzx Road, a road leading to it
- "Zzyzx Rd.", a song by Stone Sour from Come What(ever) May
- "Zzyzx Scarecrow", a song by the band Stavesacre
- Zzyzx (album), an album by Zeromancer
- Zzyzx (film), a 2005 film directed by Richard Halpern
- Zzyzx, a fictional company in the TV series Kyle XY
- Zzyzx, a fictional prison for demons in the novel series Fablehaven by Brandon Mull