Zwei may refer to:
- Two in the German language
- Zwei, a team in Infinite Ryvius anime series
- Zwei (band), a Japanese band
- ZWEI, a text editor
- Zwei!!, an action role-playing video game developed by the Nihon Falcom Corporation
- When written as "swy" it is the Australian gambling game, also known as Two-up
- My-Otome Zwei, the OVA to the My-Otome series
- GNW-002 Gundam Throne Zwei, a mobile unit in the Anno Domini continuity of the Gundam Metaseries
- Gravion Zwei, the second season of the Gravion anime series
- Zwei, an upcoming survival horror video game by Shinji Mikami