Zio can refer to the following:
- Zio, Togo, a prefecture in southern Togo
- Zio, the Italian word for uncle, or slang for friend ("bro")
- Zio a major antagonist from the video game Phantasy Star IV
- the Zonal Informatics Olympiad of the Indian Computing Olympiad
- Franck Zio, a Burkinabé long jumper
- Toyota Mark X ZiO, a crossover vehicle sold in Japan.