Z12 small nucleolar RNA is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z12 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
Famous quotes containing the word small:
“When we consider the vast distance of the known and visible parts of the world, and the reasons we have to think, that what lies within our ken is but a small part of the universe, we shall then discover an huge abyss of ignorance.”
—John Locke (1632–1704)