Yusupov (Russian: Юсупов) or Yusupova (feminine; Юсупова) is a Russian surname of Tatar (Tatar: Йосыпов; Yosıpov) origin. It may refer to:
- House of Yusupov, noble Russian family
- Felix Yusupov (1887–1967), Count Sumarokov-Elston, Russian aristocrat and one of the participants in the murder of Grigori Rasputin
- Irina Yusupova (1915–1993), Russian Princess and daughter of Count Felix Yusupov
- Zinaida Nikolaevna Yusupova (1861–1939), Russian Princess and mother of Count Felix Yusupov
- Aliya Yusupova (b. 1984), Kazakhstan gymnast
- Artur Yusupov (b. 1960), chess master
- Benjamin Yusupov (born 1962), Israeli composer of Tajik origin
- Ismail Yusupov (1913–2005), Kazakhstan politician
- Iraida Yusupova (b. 1962), Turkmenistan composer
- Lidia Yusupova (b. 1961), human rights activist
- Tuti Yusupova (b.1880?), Uzbekistani longevity claimant
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