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Yuan-ti play significant roles in various Dungeons & Dragons computer games. In Neverwinter Nights, a Yuan-ti is one of the four creatures the player must recapture to create a cure for a disease that is rampant across the city. They also play a major role in Icewind Dale, where they are ruled by a marilith named Yxunomei. In Icewind Dale II they are a late game enemy who have overrun the town of Kuldahar and must be repelled, back through the portal they arrived in, as well as being present in the 'Dragon's Eye' cave system. There is a side quest that involves a yuan-ti researcher who requires help in modifying the histachii transformation to retain his mind so he may examine the yuan-ti at close quarters. Yuan-ti appear as the main villain group in the expansion Neverwinter Nights 2: Storm of Zehir.
Yuan-ti also make appearances in Baldur's Gate II. The sarrukh - the creators of the yuan-ti - are also the primary antagonists of Neverwinter Nights.
Yuan-ti also appear in the Dungeons and Dragons Miniatures Game.
Yuan-ti also have a full region series of sidequests in the Ringing Mountains in Dark Sun: Wake of the Ravager.
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