Yeasts Include A Great Diversity of Organisms
In general, fungi are excellent hosts for the production of recombinant proteins. They offer a desired ease of genetic manipulation and rapid growth to high cell densities on inexpensive media. As eukaryotes, they are able to perform protein modifications like glycosylation (addition of sugars), thus producing even complex foreign proteins that are identical or very similar to native products from plant or mammalian sources. The first yeast expression platform was based on the commonly known baker’s yeast Saccharomyces cerevisiae. However the baker’s yeast is only one of more than 800 different yeasts with different characteristics and capabilities. For instance some of them grow on a wide range of carbon sources and are not restricted to glucose, as it is the case with baker’s yeast. Several of them are also applied to genetic engineering and to the production of foreign proteins. Here a selection:
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—Ralph Waldo Emerson (1803–1882)
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