Yayo can refer to:
- A misspelling of a slang term for cocaine, also spelled "yeyo", from the Spanish term "llello"
- José Carlos Guridi, an Argentine economist, actor, humorist and entertainer, mostly known for his work on the Argentine TV Show Videomatch and its subsequent re-boot, Showmatch.
- Santiago Luis Polanco RodrÃguez, cocaine dealer
- Tony Yayo, an American rapper and member of the rap group G-Unit
- "Yayo" a song by Lana Del Rey that appears on the album, Lana Del Ray a.k.a. Lizzy Grant and the EPs, Kill Kill and Paradise in different versions on each album.