YAF2

Identifiers Symbols YAF2; DKFZp779H1820; MGC41856 External IDs OMIM: 607534 MGI: 1914307 HomoloGene: 4203 GeneCards: YAF2 Gene

Gene Ontology
Molecular function	• transcription coactivator activity • transcription corepressor activity • protein binding • zinc ion binding • metal ion binding
Cellular component	• nucleus • nucleolus • cytoplasm
Biological process	• transcription, DNA-dependent • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10138 67057 Ensembl ENSG00000015153 ENSMUSG00000022634 UniProt Q8IY57 Q99LW6 RefSeq (mRNA) NM_001012424 NM_024189 RefSeq (protein) NP_001177906 NP_077151 Location (UCSC) Chr 12:
42.55 – 42.63 Mb Chr 15:
93.28 – 93.34 Mb PubMed search

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.