XYZ may refer to:
- Cartesian coordinate system (x,y,z)
- CIE 1931 color space, color coordinates called "XYZ"
- The XYZ Affair, American–French diplomatic incident
- XYZ file format, a chemical file format
- XYZ (UK band), an abortive rock project featuring Jimmy Page, Chris Squire and Alan White
- XYZ (US band), hard rock band
- XYZ (XYZ album), 1989 debut album
- XYZ (Andy Summers album), a 1987 solo album by Andy Summers
- XYZ (game show) a British daytime TV quiz show
- XYZ Records, a record label
- XYZnetworks, an Australian production company