Wyrm may refer to:
- Wyrms (novel), a 1987 science fiction novel by Orson Scott Card
- Wyrms (comics), a six-issue comic book mini-series by Orson Scott Card and Jake Black
- Wyrm (novel), by Mark Fabi in which a virus develops swarm intelligence on the Internet
- Wyrm (TMNT), a mutated garbageman in Teenage Mutant Ninja Turtles
- Wyrm (World of Darkness), the bringer of the apocalypse
- WYRM, a radio station in Norfolk, Virginia
- Wyrm, an alternative name for the mythological European dragon
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