Simulating Wound Healing From A Growth Perspective
Considerable effort has been devoted to understanding the physical relationships governing wound healing and subsequent scarring, with mathematical models and simulations developed to elucidate these relationships. The growth of tissue around the wound site is a result of the migration of cells and collagen deposition by these cells. The alignment of collagen describes the degree of scarring; basket-weave orientation of collagen is characteristic of normal skin, whereas aligned collagen fibers lead to significant scarring. It has been shown that the growth of tissue and extent of scar formation can be controlled by modulating the stress at a wound site.
The growth of tissue can be simulated using the aforementioned relationships from a biochemical and biomechanical point of view. The biologically active chemicals that play an important role in wound healing are modeled with Fickian diffusion to generate concentration profiles. The balance equation for open systems when modeling wound healing incorporates mass growth due to cell migration and proliferation. Here the following equation is used:
Dtρ0 = Div (R) + R0,
where ρ represents mass density, R represents a mass flux (from cell migration), and R0 represents a mass source (from cell proliferation, division, or enlargement).
Read more about this topic: Wound Healing
Famous quotes containing the words simulating, wound, healing, growth and/or perspective:
“Would it be possible to stand still on one spot more majestically—while simulating a triumphant march forward—than it is done by the two English Houses of Parliament?”
—Alexander Herzen (1812–1870)
“We cannot assume the injustice of any actions which only create offense, and especially as regards religion and morals. He who utters or does anything to wound the conscience and moral sense of others, may indeed act immorally; but, so long as he is not guilty of being importunate, he violates no right.”
—Karl Wilhelm Von Humboldt (1767–1835)
“In the deserts of the heart
Let the healing fountain start,
In the prison of his days
Teach the free man how to praise.”
—W.H. (Wystan Hugh)
“From infancy, a growing girl creates a tapestry of ever-deepening and ever- enlarging relationships, with her self at the center. . . . The feminine personality comes to define itself within relationship and connection, where growth includes greater and greater complexities of interaction.”
—Jeanne Elium (20th century)
“I know that you, ladies and gentlemen, have a philosophy, each and all of you, and that the most interesting and important thing about you is the way in which it determines the perspective in your several worlds.”
—William James (1842–1910)