Wolpe is a surname and may refer to:
- Berthold Wolpe (1905–1989), visual designer
- David Wolpe (born 1958), American Rabbi
- Harold Wolpe (born 1926–1996), South African activist and academic
- Howard Wolpe (born 1939), professor and politician from the United States
- Joseph Wolpe (1915–1997), psychiatrist
- Stefan Wolpe (1902–1972), German-American composer
- Shalom Dov Wolpo (or Wolpe), Israeli Rabbi