WLS may refer to:
- White light scanner, a device for measuring physical geometry
- WLS (AM), a radio station (890 AM)
- WLS-FM, a radio station (94.7 FM)
- WLS-TV, a television station (channel 7 analog/44 digital)
- "World's Largest Store", a former slogan of Sears and the origin of the WLS radio and television call signs
- The Chapman code for the country of Wales
- Weight loss surgery
- Weighted least squares, in statistics, a method for model fitting
- Westchester Library System, in Westchester County, New York
- Oracle Weblogic Server, a Java application server
- Windows Live Spaces
- West London Synagogue
- WLS Stamping, a metal stamping and manufacturing company
- Whittier Law School