William Sutherland is the name of:
- William Sutherland (British Army officer), fought in the American Revolutionary War
- William Sutherland (physicist) (1859-1911), Australian physicist
- William Sutherland (Ontario politician) (d. 1998), city councillor in North York, Ontario
- William Sutherland (Scottish politician) (1880–1949), Chancellor of the Duchy of Lancaster
- William Garner Sutherland (1873–1954), doctor of osteopathy
- William Charles Sutherland, Speaker of the Legislative Assembly of Saskatchewan, Canada
- William A. Sutherland (1874–1935), American lawyer and California State Assemblyman
- William Sutherland (N.W.T. politician) (1854–after 1898), general merchant and political figure in the Northwest Territories, Canada
- William R. Sutherland, better known as Bert Sutherland, prominent American technology researcher
- Bill Sutherland, Canadian ice hockey player