William Kerr is the name of:
- William Kerr, 1st Earl of Lothian (c. 1605–1675), Scottish nobleman
- Sir William Kerr, 3rd Baronet (died 1716), one of the Scottish representatives to the first Parliament of Great Britain
- William Kerr (British Army officer) (died 1741), MP for Aberdeen Burghs and Dysart Burghs
- William Kerr, 3rd Marquess of Lothian (c. 1690–1767), Scottish nobleman
- William Kerr, 4th Marquess of Lothian (1710–1775), also a Member of Parliament
- William Kerr (gardener) (died 1814), collector of plants in East Asia
- William Kerr, 6th Marquess of Lothian (1763–1824)
- William Johnson Kerr (1787–1845), political figure in Upper Canada
- William Kerr (mayor) (1809–1853), mayor of Pittsburgh, Pennsylvania
- William Franklin Kerr (1876–1968), journalist and politician in Saskatchewan, Canada
- William G. Kerr (ca. 1814–1861), mayor of Hamilton, Ontario, Canada
- William Kerr (journalist) (1812–1859), Scottish-Australian journalist
- William Alexander Kerr (1831–1919), Scottish recipient of the Victoria Cross
- William Kerr (Canadian politician) (1836–1906), Canadian politician
- William Kerr (architect) (1836–1911), Irish-American architect
- William Kerr (bishop) (1873–1960), Irish Anglican bishop
- William Munro Kerr (1876–1959), British admiral
- William Kerr (baseball), co-owner of the Pittsburgh Pirates baseball team
- William Jasper Kerr (1863–1947), president of Oregon State University, 1907–1932
- William Kerr, 2nd Marquess of Lothian (1661–1722), Scottish peer and soldier
- William Kerr, 5th Marquess of Lothian (1737–1815), British soldier and peer
- William Alexander Robb Kerr (1875–1945), Canadian academic and president of the University of Alberta
- Sir William Kerr, 4th Baronet (died 1741), of the Kerr baronets
- Sir William Kerr, 6th Baronet (died 1755), of the Kerr baronets
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