William Keppel may refer to:
- Willem Anne van Keppel, 2nd Earl of Albemarle (1702–1754)
- William Keppel (British Army officer) (1727–1787), British general
- William Keppel (governor) (d. 1834), British general and colonial administrator
- William Charles Keppel, 4th Earl of Albemarle (1772–1849)
- William Coutts Keppel, 7th Earl of Albemarle (1832–1894)