William Kelley may refer to:
- William K. Kelley, Deputy White House Counsel for the George W. Bush administration
- William Donald Kelley (1925–2005), orthodontist and inventor of alternative cancer treatments
- William D. Kelley (1814–1890), U.S. Representative from Pennsylvania
- William Melvin Kelley, novelist and professor at Sarah Lawrence College, 2008 winner of the Anisfield-Wolf Book Award for lifetime achievement
- Bill Kelley (American football), American football tight end who played for the Green Bay Packers in 1949
- Bill Kelley, host of "The Children's Hour (Dallas children's television series)" in Dallas, Texas