William Jardine may refer to:
- William Jardine (merchant), Scottish surgeon and merchant, one of the founders of Jardine, Matheson & Co.
- Sir William Jardine, 7th Baronet (1800–1874), Scottish naturalist
- William Marion Jardine (1879–1959), U.S. Secretary of Agriculture (1925–1929), U.S. Ambassador to Egypt (1930–1933)