William Irvine may refer to:
- William Irvine (soldier) (c. 1298–?), Clerk of the Rolls for Scotland
- William Irvine (physician) (1741–1804), American Revolutionary War general, congressman from Pennsylvania
- William Irvine (lawyer) (1820–1882), American Civil War soldier, congressman from New York
- William Irvine (Australian politician) (1858–1943), Premier of Victoria
- William Irvine (Scottish evangelist) (1863–1947), evangelist considered the founder of various nameless sects
- William Irvine (Canadian politician) (1885–1962), Canadian politician
- William C. Irvine (missionary), editor of the Indian Christian and author of Modern Heresies Exposed (1917).
- William Irvine, (1906-1964) professor of English at Stanford University
- William Irvine (Rhodesian politician) (fl.1980s)
- William D. Irvine (b.1950s?), Canadian historian
- Willie Irvine (b.1943), footballer from Northern Ireland, played for Burnley, Preston, Brighton & Hove Albion and Northern Ireland
- Willie Irvine (footballer born 1956), Scottish footballer, played for Alloa, Motherwell and Hibernian
- Willie Irvine (footballer born 1963), Scottish footballer, played for Hibernian, Airdrie, Dunfermline, Alloa and Stenhousemuir
- Bill Irvine, ballroom dancer