Wilkerson is a surname. Notable people with the surname include:
- Brad Wilkerson (born 1977), American baseball player
- Cathlyn Platt Wilkerson (born 1945), American radical and member of the Weather Underground
- David Wilkerson (1931–2011), American evangelist
- Gerald Eugene Wilkerson (born 1939), Auxiliary Bishop of the Roman Catholic Archdiocese of Los Angeles
- Isaiah Wilkerson (born 1990), American basketball player
- James Herbert Wilkerson (1869–1948), US federal judge
- Jerry O. Wilkerson (1943–2007), American painter
- Kimberly Wilkerson, former Miss Wyoming
- Lawrence Wilkerson (born 1945), U.S. Army officer, deputy to Colin Powell
- Mark Wilkerson (born 1976), lead singer and guitarist of the rock band Course of Nature
- Nathaniel P. Wilkerson (born 1972), Gitksan artist from British Columbia, Canada
- Pinkie C. Wilkerson (1948–2000), African American Louisiana state representative
- Ponchai Wilkerson (1971–2000), American murderer who was executed in Texas
- Robert King Wilkerson, Black Panther Party member
- Tichi Wilkerson Kassel (1926–2004), American film personality and the publisher of The Hollywood Reporter
- Tim Wilkerson (born 1960), NHRA drag racer
- Wallace Wilkerson (c. 1834–1879), American murderer whose execution by firing squad in Utah was botched
- William Wilkerson (1890–1962), founder of The Hollywood Reporter, Ciro's, and the Flamingo Hotel
Fictional characters:
- Wilkerson, the family name in the television show Malcolm in the Middle
Read more about Wilkerson: See Also