Wilke is a surname, and may refer to:
- Birthe Wilke, Danish singer
- C.R. Wilke, a chemical engineer most famous for one of the most important correlations in mass transfer, the Wilke-Chang correlation, which was developed with Pin Chang in 1955 and measures diffusion coefficients between two molecules.
- Hannah Wilke, American sculptor
- Julius A. R. Wilke, American Medal of Honor recipient
- Kristof Wilke (b. 1985), German rower
- Robert J. Wilke, American actor
- Rudolf Wilke, German caricaturist