Wesson may refer to, among other things:
- Wesson, Mississippi, a town in Copiah County
- Wesson, Arkansas, a township in Union County, Arkansas
- Wesson cooking oil, a brand now owned by ConAgra Foods, Inc.
- USS Wesson (DE-184), a United States Navy destroyer escort
Notable people named Wesson include:
- Daniel B. Wesson, co-inventor of the Winchester rifle and co-founder of Smith & Wesson
- Daniel B. Wesson II, great-grandson of Daniel B. Wesson, founder Dan Wesson Firearms
- Dick Wesson, actor and announcer for The Wonderful World of Disney
- Edward Wesson, an English watercolour artist
- Herb Wesson, former Speaker of the California State Assembly and current Los Angeles City Councilman
- Marcus Wesson, a convicted American mass murderer
- Tina Wesson, the winner of the reality television program Survivor: The Australian Outback