Werner Syndrome ATP-dependent Helicase
| Gene Ontology | |
|---|---|
| Molecular function | • magnesium ion binding • Y-form DNA binding • bubble DNA binding • DNA binding • DNA helicase activity • ATP-dependent DNA helicase activity • helicase activity • exonuclease activity • protein binding • ATP binding • 3'-5' exonuclease activity • four-way junction helicase activity • ATPase activity • manganese ion binding • protein complex binding • protein homodimerization activity • 3'-5' DNA helicase activity • ATP-dependent 3'-5' DNA helicase activity • G-quadruplex DNA binding |
| Cellular component | • nucleus • nucleoplasm • nucleolus • centrosome • MutLalpha complex |
| Biological process | • telomere maintenance • DNA synthesis involved in DNA repair • replicative cell aging • ATP catabolic process • DNA metabolic process • DNA replication • base-excision repair • double-strand break repair • DNA recombination • response to DNA damage stimulus • response to oxidative stress • aging • cell aging • cellular response to starvation • response to UV-C • multicellular organismal aging • replication fork processing • nucleolus to nucleoplasm transport • DNA duplex unwinding • regulation of growth rate • regulation of apoptotic process • positive regulation of hydrolase activity • cellular response to gamma radiation |
| Sources: Amigo / QuickGO | |
30.89 – 31.03 Mb
33.23 – 33.39 Mb
WRN (Werner syndrome) is a human gene that provides instructions for producing Werner protein, which is a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA.
The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.
Read more about Werner Syndrome ATP-dependent Helicase: Related Conditions, Interactions
Famous quotes containing the word syndrome:
“Women are taught that their main goal in life is to serve others—first men, and later, children. This prescription leads to enormous problems, for it is supposed to be carried out as if women did not have needs of their own, as if one could serve others without simultaneously attending to one’s own interests and desires. Carried to its “perfection,” it produces the martyr syndrome or the smothering wife and mother.”
—Jean Baker Miller (20th century)