Werner Syndrome ATP-dependent Helicase

Werner Syndrome ATP-dependent Helicase

Identifiers Symbols WRN; RECQ3; RECQL2; RECQL3 External IDs OMIM: 604611 MGI: 109635 HomoloGene: 6659 GeneCards: WRN Gene EC number 3.6.4.12

Gene Ontology
Molecular function	• magnesium ion binding • Y-form DNA binding • bubble DNA binding • DNA binding • DNA helicase activity • ATP-dependent DNA helicase activity • helicase activity • exonuclease activity • protein binding • ATP binding • 3'-5' exonuclease activity • four-way junction helicase activity • ATPase activity • manganese ion binding • protein complex binding • protein homodimerization activity • 3'-5' DNA helicase activity • ATP-dependent 3'-5' DNA helicase activity • G-quadruplex DNA binding
Cellular component	• nucleus • nucleoplasm • nucleolus • centrosome • MutLalpha complex
Biological process	• telomere maintenance • DNA synthesis involved in DNA repair • replicative cell aging • ATP catabolic process • DNA metabolic process • DNA replication • base-excision repair • double-strand break repair • DNA recombination • response to DNA damage stimulus • response to oxidative stress • aging • cell aging • cellular response to starvation • response to UV-C • multicellular organismal aging • replication fork processing • nucleolus to nucleoplasm transport • DNA duplex unwinding • regulation of growth rate • regulation of apoptotic process • positive regulation of hydrolase activity • cellular response to gamma radiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7486 22427 Ensembl ENSG00000165392 ENSMUSG00000031583 UniProt Q14191 O09053 RefSeq (mRNA) NM_000553 NM_001122822 RefSeq (protein) NP_000544 NP_001116294 Location (UCSC) Chr 8:
30.89 – 31.03 Mb Chr 8:
33.23 – 33.39 Mb PubMed search

WRN (Werner syndrome) is a human gene that provides instructions for producing Werner protein, which is a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA.

The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.