Introduction
The regulation of cell size is critical to ensure functionality of a cell. Besides environmental factors such as nutrients, growth factors and functional load, cell size is also controlled by a cellular cell size checkpoint.
Wee1 is a component of this checkpoint. It is a kinase determining the timepoint of entry into mitosis, thus influencing the size of the daughter cells. Loss of Wee1 function will produce smaller than normal daughter cell, because cell division occurs prematurely.
Its name is derived from the Scottish dialect word wee, meaning small - its discoverer Paul Nurse was working at the University of Edinburgh in Scotland at the time of discovery.
Read more about this topic: Wee1
Famous quotes containing the word introduction:
“My objection to Liberalism is thisthat it is the introduction into the practical business of life of the highest kindnamely, politicsof philosophical ideas instead of political principles.”
—Benjamin Disraeli (18041881)
“The role of the stepmother is the most difficult of all, because you cant ever just be. Youre constantly being testedby the children, the neighbors, your husband, the relatives, old friends who knew the childrens parents in their first marriage, and by yourself.”
—Anonymous Stepparent. Making It as a Stepparent, by Claire Berman, introduction (1980, repr. 1986)
“We used chamber-pots a good deal.... My mother ... loved to repeat: When did the queen reign over China? This whimsical and harmless scatological pun was my first introduction to the wonderful world of verbal transformations, and also a first perception that a joke need not be funny to give pleasure.”
—Angela Carter (19401992)