Cast
- James McAvoy as Wesley Allan Gibson, a meek 24-year-old who works in a cubicle, but learns he is heir to a legacy of assassins.
- Morgan Freeman as Sloan, leader of the Fraternity, and assassin partner of Wesley Gibson's deceased "father".
- Angelina Jolie as Fox, an accomplished member of the Fraternity who mentors Gibson.
- Thomas Kretschmann as Cross, a rogue assassin who has left the Fraternity and is the true biological father of Wesley.
- Common as Earl Malcolm Spellman a.k.a. "The Gunsmith", a professional gunman who trains others to use weapons.
- Konstantin Khabensky as The Exterminator, an expert in explosives who makes bombs and attaches them to rats. One of Wesley's only friends in the Fraternity.
- Marc Warren as The Repairman, an assassin who says he "breaks bad habits" by violently beating people. Trains Wesley in hand-to-hand combat and endurance.
- Dato Bakhtadze as The Butcher, a master of knife work to the extent that he can block bullets. Trains Wesley in knife fighting.
- Terence Stamp as Pekwarsky, a master in the science of killing. Pekwarsky operates as a rogue agent outside of The Fraternity. He is also a craftsman who is able to build bullets both untraceable and capable of traversing long distances. One of Cross's compatriots.
- David O'Hara as Mr. X, said to be the greatest assassin, and believed to be Wesley's father. His murder is the catalyst for Wesley's introduction into the Fraternity. He is the first Fraternity member to die onscreen.
- Chris Pratt as Barry, Gibson's co-worker and best friend, who is having an affair with Gibson's girlfriend. His saying "You're the man!" to Wesley becomes a running gag throughout the film.
- Kristen Hager as Cathy, Gibson's unfaithful and bickering girlfriend.
- Sophiya Haque as Puja
- Lorna Scott as Janice, Gibson's overbearing boss.
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