VSD may refer to:
- Vaccine Safety Datalink, a Centers for Disease Control database containing vaccination and health records of over 7 million Americans
- Variable speed drive, or adjustable-speed drive, is a specific type of a variable-frequency drive
- VSD (French magazine) (Vendredi Samedi Dimanche; i.e. "Friday Saturday Sunday"), a French weekly news magazine
- Ventricular septal defect, a defect in the ventricular septum of the heart
- Video Single Disc, a video disc format based on laserdisc that only was popular in Japan and the rest of Asia
- Virtually safe dose, a concept in regulatory toxicology, applied to carcinogens with no threshold of effects
- .vsd, a file extension for Microsoft Visio diagrams
- Visible surface determination, also known as Hidden surface determination
- Victory Star Destroyer, a fictional ship in the Star Wars universe
Read more about VSD: Places