VSC may refer to:
- Valley Stream Central High School in Valley Stream, NY
- Debreceni VSC, a Hungarian football club
- Volunteer Special Constabulary, a component of the Singapore Police Force
- Vermont State Colleges, a consortium of public colleges in the U.S. state of Vermont and its governance body
- Vermont Studio Center, a fine arts and writing residency program located at Johnson in the U.S. state of Vermont
- Vietnam Solidarity Campaign, a Vietnam War-era activist group
- Vessel Safety Checks of recreational boaters
- Versatile Surface Combatant, a successor to the British Royal Navy's Future Surface Combatant program
- Vinlanders Social Club
- The Volunteer Service Corp at Wake Forest University
- Abbreviation for rulings of the Supreme Court of Victoria, Australia
- ICAO airline designator for the Colombian airline operator AVESCA AerovĂas Especiales de Carga
- Vision Skill Consulting Limited, a Hong Kong business consultancy
Read more about VSC: Technology, Medicine