Television, Film, Music, and Manga
- Vanilla Sky, a 2001 film
- Vocal Spectrum, the Barbershop Harmony Society's 2006 International Quartet Champions
- VS (band), band managed by Blue's Simon Webbe
- Vs (film), a 2011 film
- VS (manga), Japanese manga by Keiko Yamada
- VS (song), the debut single by Misono
- VS. (game show), a game show with two opposing teams
- Vs. (Mission of Burma album), a 1982 album by Mission of Burma
- Vs. (Pearl Jam album), a 1993 album by Pearl Jam
- "VS.", season 4 episode of Prison Break
- "VS. (Versus)", former name of the NBC Sports Network
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