VPI may refer to:
- Vietnam Petroleum Institute
- Virginia Polytechnic Institute and State University (a.k.a. Virginia Tech)
- Virtual Path Identifier, in computer networking
- Verilog Procedural Interface, in computer programming
- Velopharyngeal insufficiency, a medical term
- Vertical Politics Institute, a conservative PAC
- VPI Industries, a manufacturer of phonographs
- Vacuum Pressure Impregnation